Abstract
Genomics comprises several distinct areas of research; transcriptomics, the study of global RNA expression; genotyping, measurement of DNA polymorphisms and mutations; and bioinformatics, the systematic analysis of biological data generated by technologies such as genomics. The field of genomics has had a rocky past, not only in toxicology, but in the biomedical sciences in general. This is due primarily to the nature of the studies. In a major shift from the research paradigm that has dominated research since the earliest philosophers and thinkers, genomics studies do not require a hypothesis. They are, in fact, considered “hypothesis generating.” Other ways of describing the genomic approach are, “not hypothesis limited” or “discovery-based” investigations. For scientists trained from their earliest science fair projects in the absolute requirement for a testable hypothesis, genomics is indeed a “fishing expedition” and unfamiliar territory.
| Original language | English |
|---|---|
| Title of host publication | Information Resources in Toxicology, Fourth Edition |
| Publisher | Elsevier |
| Pages | 345-355 |
| Number of pages | 11 |
| ISBN (Electronic) | 9780123735935 |
| DOIs | |
| State | Published - Jan 1 2009 |
Funding
This publication was made possible by Grant Number RR017670 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). The views expressed in this publication do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of tradenames, commercial practices, or organizations imply endorsement by the U.S. Government. ‘Ensembl is a joint project between EMBL-EBI and the Sanger Institute to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. Ensembl is primarily funded by the Wellcome Trust.’
| Funders |
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| Wellcome Trust |