gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi

D. S. Samuels, R. T. Marconi, Mun Huang Wai Mun Huang, C. F. Garon

Research output: Contribution to journalComment/debate

Abstract

We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.

Original languageEnglish
Pages (from-to)3072-3075
Number of pages4
JournalJournal of Bacteriology
Volume176
Issue number10
DOIs
StatePublished - 1994

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