@article{ab8cdcc9ee564e3b9a51556b44d3d61e,
title = "gyrB mutations in coumermycin A1-resistant Borrelia burgdorferi",
abstract = "We have isolated and characterized mutants of Borrelia burgdorferi that are resistant to the antibiotic coumermycin A1, which targets the B subunit of DNA gyrase. Mutants had either 100- or 300-fold higher resistance to coumermycin A1 than wild-type B. burgdorferi. In each case, a single point mutation in the gyrB gene converted Arg-133 to Gly or Ile. Mutations in the homologous Arg residue of Escherichia coli DNA gyrase are also associated with resistance to coumarin antimicrobial agents.",
author = "Samuels, \{D. S.\} and Marconi, \{R. T.\} and \{Wai Mun Huang\}, \{Mun Huang\} and Garon, \{C. F.\}",
year = "1994",
doi = "10.1128/jb.176.10.3072-3075.1994",
language = "English",
volume = "176",
pages = "3072--3075",
journal = "Journal of Bacteriology",
issn = "0021-9193",
publisher = "American Society for Microbiology",
number = "10",
}