Heterotrimeric G Proteins

S. R. Sprang, D. L. DeCamp

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Heterotrimeric G proteins are cytosolic, membrane-associated proteins that transduce neuromodulatory signals within autonomic, sensory, and central nervous system neurons. Activated by G protein-coupled receptors embedded in the pre- and postsynaptic membranes of neurons, G proteins control the activities of ion channels and enzymes that generate intracellular second messenger molecules. The G. α and G. βγ components of heterotrimeric G proteins have both independent and tightly coordinated roles in the regulation of these effectors. G protein activation is controlled by G protein-coupled receptors and GTPase-activating proteins that respectively stimulate guanosine triphosphate binding and hydrolysis by Gα.

Original languageEnglish
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Pages560-563
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
DOIs
StatePublished - Jan 1 2014

Keywords

  • Adenylyl cyclase
  • Calcium channels
  • G protein alpha subunit
  • G protein βγ
  • G protein-coupled receptors
  • GTPase-activating proteins
  • Neurophysiology
  • Neurotransmitters
  • Phospholipase C-β
  • Potassium channels
  • Signal transduction

Fingerprint

Dive into the research topics of 'Heterotrimeric G Proteins'. Together they form a unique fingerprint.

Cite this