Heterotrimeric G Proteins

S. R. Sprang, D. L. DeCamp

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Heterotrimeric G proteins are cytosolic, membrane-associated proteins that transduce neuromodulatory signals within autonomic, sensory, and central nervous system neurons. Activated by G protein-coupled receptors embedded in the pre- and postsynaptic membranes of neurons, G proteins control the activities of ion channels and enzymes that generate intracellular second messenger molecules. The G. α and G. βγ components of heterotrimeric G proteins have both independent and tightly coordinated roles in the regulation of these effectors. G protein activation is controlled by G protein-coupled receptors and GTPase-activating proteins that respectively stimulate guanosine triphosphate binding and hydrolysis by Gα.

Original languageEnglish
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Adenylyl cyclase
  • Calcium channels
  • G protein alpha subunit
  • G protein βγ
  • G protein-coupled receptors
  • GTPase-activating proteins
  • Neurophysiology
  • Neurotransmitters
  • Phospholipase C-β
  • Potassium channels
  • Signal transduction


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