Human Papillomavirus Vaccine Effectiveness Against Incident Genital Warts among Female Health-Plan Enrollees, United States

Susan Hariri, Megan S. Schuler, Allison L. Naleway, Matthew F. Daley, Sheila Weinmann, Bradley Crane, Sophia R. Newcomer, Dennis Tolsma, Lauri E. Markowitz

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the effectiveness of human papillomavirus vaccination by dose number and spacing against incident genital warts in a cohort of 64,517 female health-plan enrollees in the United States during 2006-2012. Eligible recipients were classified into groups by regimen: 0, 1, 2 (<6 months apart), 2 (≥6 months apart), or 3 doses. They were followed until a genital wart diagnosis, loss to follow-up, or the end of study. Propensity score weights were used to balance baseline differences across groups. To account for latent genital warts before vaccination, we applied 6- and 12-month buffer periods from last and first vaccine dose, respectively. Incidence rates and hazard ratios were calculated using Poisson regression and Cox models. The propensity score-weighted incidence rate per 100,000 person-years was 762 among unvaccinated participants. Using 6- and 12-month buffer periods, respectively, incidence rates were 641 and 257 for 1 dose, 760 and 577 for the 2-dose (<6-month interval) regimen, 313 and 194 for the 2-dose (≥6-month interval) regimen, and 199 and 162 among 3-dose vaccinees; vaccine effectiveness was 68% and 76% for the 2-dose (≥6-month interval) regimen and 77% and 80% in 3-dose vaccinees compared with unvaccinated participants. Vaccine effectiveness was not significant among vaccinees receiving 1-dose and 2-dose (<6-month interval) regimens compared with unvaccinated participants. Our findings contribute to a better understanding of the real-world effectiveness of HPV vaccination.

Original languageEnglish
Pages (from-to)298-305
Number of pages8
JournalAmerican Journal of Epidemiology
Volume187
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • genital warts
  • human papillomavirus vaccine
  • vaccine effectiveness

Fingerprint

Dive into the research topics of 'Human Papillomavirus Vaccine Effectiveness Against Incident Genital Warts among Female Health-Plan Enrollees, United States'. Together they form a unique fingerprint.

Cite this