Hyaluronan chemistries for three-dimensional matrix applications

Monica A. Serban, Aleksander Skardal

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Hyaluronan is a ubiquitous constituent of mammalian extracellular matrices and, because of its excellent intrinsic biocompatibility and chemical modification versatility, has been widely employed in a multitude of biomedical applications. In this article, we will survey the approaches used to tailor hyaluronan to specific needs of tissue engineering, regenerative and reconstructive medicine and overall biomedical research. We will also describe recent examples of applications in these broader areas, such as 3D cell culture, bioprinting, organoid biofabrication, and precision medicine that are facilitated by the use of hyaluronan as a biomaterial.

Original languageEnglish
Pages (from-to)337-345
Number of pages9
JournalMatrix Biology
StatePublished - May 2019


  • Biofabrication
  • Bioink
  • Biomaterial
  • Bioprinting
  • Dermal filler
  • Hyaluronic acid
  • Hydrogel
  • Organoid
  • Wound healing


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