Abstract
Hyaluronan is a ubiquitous constituent of mammalian extracellular matrices and, because of its excellent intrinsic biocompatibility and chemical modification versatility, has been widely employed in a multitude of biomedical applications. In this article, we will survey the approaches used to tailor hyaluronan to specific needs of tissue engineering, regenerative and reconstructive medicine and overall biomedical research. We will also describe recent examples of applications in these broader areas, such as 3D cell culture, bioprinting, organoid biofabrication, and precision medicine that are facilitated by the use of hyaluronan as a biomaterial.
| Original language | English |
|---|---|
| Pages (from-to) | 337-345 |
| Number of pages | 9 |
| Journal | Matrix Biology |
| Volume | 78-79 |
| DOIs | |
| State | Published - May 2019 |
Funding
We thank our mentor Dr. Glenn D. Prestwich for entrusting us to carry forward the torch of hyaluronan biomaterials research. No funding was received for the preparation of this review. Neither author has any conflicts of interest to disclose.
Keywords
- Biofabrication
- Bioink
- Biomaterial
- Bioprinting
- Dermal filler
- Hyaluronic acid
- Hydrogel
- Organoid
- Wound healing