Identification and interpretation of complexity in sedimentation velocity boundaries

Borries Demeler, Hashim Saber, Jeffrey C. Hansen

Research output: Contribution to journalArticlepeer-review


Synthetic sedimentation velocity boundaries were generated using finite- element solutions to the original and modified forms of the Lamm equation. Situations modeled included ideal single- and multicomponent samples, concentration-dependent samples, noninteracting multicomponent samples, and reversibly self-associating samples. Synthetic boundaries subsequently were analyzed using the method of van Halde and Weischet, and results were compared against known input parameters. Results indicate that this analytical method provides rigorous diagnostics for virtually every type of sample complexity encountered experimentally. Accordingly, both the power and utility of sedimentation velocity experiments have been significantly expanded.

Original languageEnglish
Pages (from-to)397-407
Number of pages11
JournalBiophysical Journal
Issue number1
StatePublished - Jan 1997


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