Immunoglobulin, Subclasses and Functions

David Shepherd

doi:10.1007/978-3-642-54596-2_766

Immunoglobulin, Subclasses and Functions

David Shepherd

Biomedical and Pharmaceutical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Immunoglobulins (Ig) are a family of proteins produced exclusively by B lymphocytes that mediate humoral immune responses. Human Ig are comprised of nine subclasses that have varying effector functions in the adaptive immune response to specific antigens. Characteristics Humoral immunity is mediated by a variety of B-lymphocyte-derived immunoglobulins that invoke multiple effector functions. Based on the antigenic uniqueness of their heavy chains, five human immunoglobulin (Ig) classes or isotypes have been identified and include IgA, IgD, IgE, IgG, and IgM. In addition, IgA and IgG can be further subdivided into closely related subclasses, IgA1 and IgA2 and IgG1, IgG2, IgG3, and IgG4, respectively. Some immunoglobulins are secreted into the plasma and are called antibodies, whereas others are….

Original language	English
Title of host publication	Encyclopedia of Immunotoxicology
Subtitle of host publication	Second Edition
Publisher	Springer Berlin Heidelberg
Pages	453-457
Number of pages	5
ISBN (Electronic)	9783642545962
ISBN (Print)	9783642545955
DOIs	https://doi.org/10.1007/978-3-642-54596-2_766
State	Published - Jan 1 2015

Keywords

Antibody
B-cell antigen receptor
Immunoglobulin
Immunoglobulin A (IgA)
Immunoglobulin D (IgD)
Immunoglobulin E (IgE)
Immunoglobulin G (IgG)
Immunoglobulin M (IgM)

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10.1007/978-3-642-54596-2_766

Cite this

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title = "Immunoglobulin, Subclasses and Functions",

abstract = "Immunoglobulins (Ig) are a family of proteins produced exclusively by B lymphocytes that mediate humoral immune responses. Human Ig are comprised of nine subclasses that have varying effector functions in the adaptive immune response to specific antigens. Characteristics Humoral immunity is mediated by a variety of B-lymphocyte-derived immunoglobulins that invoke multiple effector functions. Based on the antigenic uniqueness of their heavy chains, five human immunoglobulin (Ig) classes or isotypes have been identified and include IgA, IgD, IgE, IgG, and IgM. In addition, IgA and IgG can be further subdivided into closely related subclasses, IgA1 and IgA2 and IgG1, IgG2, IgG3, and IgG4, respectively. Some immunoglobulins are secreted into the plasma and are called antibodies, whereas others are….",

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KW - Antibody

KW - B-cell antigen receptor

KW - Immunoglobulin

KW - Immunoglobulin A (IgA)

KW - Immunoglobulin D (IgD)

KW - Immunoglobulin E (IgE)

KW - Immunoglobulin G (IgG)

KW - Immunoglobulin M (IgM)

UR - https://www.scopus.com/pages/publications/105010427479

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DO - 10.1007/978-3-642-54596-2_766

M3 - Chapter

AN - SCOPUS:105010427479

SN - 9783642545955

SP - 453

EP - 457

BT - Encyclopedia of Immunotoxicology

PB - Springer Berlin Heidelberg

ER -

Immunoglobulin, Subclasses and Functions

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