Impact of the Wood-Burning Justa Cookstove on Glycated Hemoglobin (HbA1c): A Stepped-Wedge Randomized Trial in Rural Honduras

BACKGROUND: Type 2 diabetes is a rapidly growing global health challenge in low-and middle-income countries (LMICs), and evidence suggests that air pollution exposure contributes. Household air pollution from burning solid fuels for cooking is a major burden in LMICs, but studies demonstrating associations between reductions in household air pollution and improvements in HbA1c, a biomarker of diabetes risk, are lacking. We previously reported substantial reductions in fine particulate matter with an aerodynamic diameter ≤2:5 lm (PM_2:5 ) and black carbon concentrations following an intervention in rural Honduras with the Justa cookstove, a wood-burning stove with an engineered combustion chamber and chimney. OBJECTIVE: In a stepped-wedge randomized controlled trial among 230 Honduran women using traditional wood-burning stoves at baseline, we evaluated the effect of the Justa intervention on HbA1c and characterized the longitudinal associations between air pollution exposures and HbA1c. METHODS: At each of six visits over 3 y, we measured 24-h PM_2:5 and black carbon concentrations, and finger-stick HbA1c levels. We used linear mixed models in intent-to-treat (condition by assigned stove type), exposure–response (using 24-h measures and modeled estimates of long-term exposures), and “per protocol” self-reported stove use analyses. RESULTS: HbA1c was reduced for the Justa condition in comparison with the traditional stove condition, but estimates were small and not statistically significant [−0:03 percentage points, 95% confidence interval (CI): −0:13, 0.07, n = 1,208 observations]. A slightly stronger effect was observed when using self-reported stove use in per protocol analyses. Exposure–response analyses demonstrated positive associations between HbA1c and air pollution [e.g., HbA1c was 0.22 percentage points higher (95% CI: 0.13, 0.30) per log-unit higher long-term average personal PM_2:5 ]. DISCUSSION: Our study provides novel evidence of exposure–response associations between household air pollution and HbA1c within a randomized cookstove trial, contributing to the evidence base necessary to support clean cooking policy initiatives. https://doi.org/10.1289/EHP15095.