Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings

Yousef R. Mirzaei, Matthew J. Weaver, Scott A. Steiger, Alison K. Kearns, Mariusz P. Gajewski, Kevin C. Rider, Howard D. Beall, N. R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

A critical comparison of methods to prepare sterically hindered 3-aryl isoxazoles containing fused aromatic rings using the nitrile oxide cycloaddition (NOC) reveal that modification of the method of Bode, Hachisu, Matsuura, and Suzuki (BHMS), utilizing either triethylamine as base or sodium enolates of the diketone, ketoester, and ketoamide dipolarophiles, respectively, was the method of choice for this transformation.

Original languageEnglish
Pages (from-to)10360-10364
Number of pages5
JournalTetrahedron
Volume68
Issue number50
DOIs
StatePublished - Dec 16 2012

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