Increased urinary phthalate levels in women with uterine leiomyoma: A case-control study

Young Ah Kim, Younglim Kho, Kyoung Chul Chun, Jae Whoan Koh, Jeong Woo Park, Melisa Bunderson-Schelvan, Yoon Hee Cho

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We assessed the urinary concentration of 16 phthalate metabolites in 57 women with and without uterine leiomyoma (n = 30 and 27; respectively) to determine the association between phthalate exposure and uterine leiomyoma. To evaluate exposure to di-(2-ethylhexyl) phthalate (DEHP); we calculated the molar sum of DEHP metabolites; ∑3-DEHP (combining mono-(2-ethylhexyl) phthalate (MEHP); mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP); and mono-(2-ethyl-5-oxohexyl) phthalate); ∑4-DEHP (∑3-DEHP plus mono-(2-ethyl-5-carboxypentyl) phthalate); and ∑5-DEHP (∑4-DEHP plus mono (2-(carboxylmethyl)hexyl) phthalate (2cx-MMHP)). The log transformed urinary levels of MEHP; MEHHP; 2cx-MMHP; ∑3-DEHP; ∑4-DEHP; and ∑5-DEHP in the leiomyoma group were significantly higher than those of controls. When we adjusted for age; waist circumference; and parity using multiple logistic regression analyses; we found log ∑3-DEHP (OR = 10.82; 95% CI = 1.25; 93.46) and ∑4-DEHP (OR = 8.78; 95% CI = 1.03; 75.29) were significantly associated with uterine leiomyoma. Our findings suggest an association between phthalate exposure and uterine leiomyoma. However; larger studies are needed to investigate potential interactions between phthalate exposure and uterine leiomyoma.

Original languageEnglish
Article number1247
JournalInternational Journal of Environmental Research and Public Health
Volume13
Issue number12
DOIs
StatePublished - Dec 15 2016

Keywords

  • Phthalates
  • Uterine leiomyoma
  • ∑3-DEHP
  • ∑4-DEHP

Fingerprint

Dive into the research topics of 'Increased urinary phthalate levels in women with uterine leiomyoma: A case-control study'. Together they form a unique fingerprint.

Cite this