Inflammatory Cells of the Lung: Macrophages

F. Jessop, K. L. Trout, A. Holian, C. Migliaccio

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The purpose of this article is to provide an overview on the lung macrophage, its role in the regulation of lung immunity, its response to toxic exposures and consequences to the host. These topics are extensive and it would be possible to dedicate an entire volume to these issues. In addition, there is much that we do not know about the regulation of the macrophage response to toxic exposures and the role of the macrophage in lung injury. The first portion of this article will describe the normal structure and functions of the macrophage in the lung and the second portion will address macrophage responses to xenobiotic exposures.

Original languageEnglish
Title of host publicationRespiratory Toxicology
PublisherElsevier Inc.
Pages94-114
Number of pages21
Volume15-15
ISBN (Electronic)9780081006122
ISBN (Print)9780081006016
DOIs
StatePublished - 2018

Keywords

  • Adaptive immunity
  • Alternative activation
  • Alveolar
  • Antigen presenting cell
  • Apoptosis
  • Asbestos
  • Autophagy
  • Bone marrow-derived
  • IL-1β
  • Inflammasome
  • Inflammation
  • Innate immunity
  • Interleukins
  • Interstitial
  • M nomenclature
  • Macrophage
  • Major histocompatibility complex
  • Monocytes
  • Nanomaterial
  • Particulates
  • Phagocytosis
  • Pulmonary
  • Regulation
  • Silica
  • Subsets
  • TGF-α
  • TNFα
  • Xenobiotic

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