TY - JOUR
T1 - Influence of carbohydrate on immune function following 2 h cycling
AU - Nieman, David C.
AU - Henson, Dru A.
AU - Gojanovich, Greg
AU - Davis, J. Mark
AU - Murphy, E. Angela
AU - Mayer, Eugene P.
AU - Pearce, Steven
AU - Dumke, Charles L.
AU - Utter, Alan C.
AU - McAnulty, Steven R.
AU - McAnulty, Lisa S.
N1 - Funding Information:
Received 28 December 2005; accepted 20 May 2006. Supported by a grant from the Gatorade Sports Science Institute. We acknowledge the skillful assistance of Nathaniel Bailey, Jessica Eaton, and Kevin Oley in this research project. Address correspondence to David C. Nieman, DrPH, FACSM, Department of Health, Leisure, & Exercise Science, P.O. Box 32071, Appalachian State University, Boone, NC 28608, USA. E-mail: [email protected]
PY - 2006/9/1
Y1 - 2006/9/1
N2 - The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64% Wattsmax while receiving 4 mL·kg-1·15 min-1 carbohydrate (6%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.
AB - The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64% Wattsmax while receiving 4 mL·kg-1·15 min-1 carbohydrate (6%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.
KW - Exercise
KW - Lymphocytes
KW - Natural killer cells
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=33747701616&partnerID=8YFLogxK
U2 - 10.1080/15438620600854793
DO - 10.1080/15438620600854793
M3 - Article
C2 - 16967774
AN - SCOPUS:33747701616
SN - 1543-8627
VL - 14
SP - 225
EP - 237
JO - Research in Sports Medicine
JF - Research in Sports Medicine
IS - 3
ER -