Influence of carbohydrate on immune function following 2 h cycling

David C. Nieman; Dru A. Henson; Greg Gojanovich; J. Mark Davis; E. Angela Murphy; Eugene P. Mayer; Steven Pearce; Charles L. Dumke; Alan C. Utter; Steven R. McAnulty; Lisa S. McAnulty

doi:10.1080/15438620600854793

Influence of carbohydrate on immune function following 2 h cycling

David C. Nieman
, Dru A. Henson
, Greg Gojanovich
, J. Mark Davis
, E. Angela Murphy
, Eugene P. Mayer
, Steven Pearce
, Charles L. Dumke
, Alan C. Utter
, Steven R. McAnulty
, Lisa S. McAnulty

School of Integrative Physiology and Athletic Training

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64% Watts_max while receiving 4 mL·kg^-1·15 min^-1 carbohydrate (6%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.

Original language	English
Pages (from-to)	225-237
Number of pages	13
Journal	Research in Sports Medicine
Volume	14
Issue number	3
DOIs	https://doi.org/10.1080/15438620600854793
State	Published - Sep 1 2006

Funding

Received 28 December 2005; accepted 20 May 2006. Supported by a grant from the Gatorade Sports Science Institute. We acknowledge the skillful assistance of Nathaniel Bailey, Jessica Eaton, and Kevin Oley in this research project. Address correspondence to David C. Nieman, DrPH, FACSM, Department of Health, Leisure, & Exercise Science, P.O. Box 32071, Appalachian State University, Boone, NC 28608, USA. E-mail: [email protected]

Keywords

Exercise
Lymphocytes
Natural killer cells
T cells

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10.1080/15438620600854793

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title = "Influence of carbohydrate on immune function following 2 h cycling",

abstract = "The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64\% Wattsmax while receiving 4 mL·kg-1·15 min-1 carbohydrate (6\%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.",

keywords = "Exercise, Lymphocytes, Natural killer cells, T cells",

author = "Nieman, \{David C.\} and Henson, \{Dru A.\} and Greg Gojanovich and Davis, \{J. Mark\} and Murphy, \{E. Angela\} and Mayer, \{Eugene P.\} and Steven Pearce and Dumke, \{Charles L.\} and Utter, \{Alan C.\} and McAnulty, \{Steven R.\} and McAnulty, \{Lisa S.\}",

note = "Funding Information: Received 28 December 2005; accepted 20 May 2006. Supported by a grant from the Gatorade Sports Science Institute. We acknowledge the skillful assistance of Nathaniel Bailey, Jessica Eaton, and Kevin Oley in this research project. Address correspondence to David C. Nieman, DrPH, FACSM, Department of Health, Leisure, \& Exercise Science, P.O. Box 32071, Appalachian State University, Boone, NC 28608, USA. E-mail: [email protected]",

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AU - Henson, Dru A.

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AU - Davis, J. Mark

AU - Murphy, E. Angela

AU - Mayer, Eugene P.

AU - Pearce, Steven

AU - Dumke, Charles L.

AU - Utter, Alan C.

AU - McAnulty, Steven R.

AU - McAnulty, Lisa S.

N1 - Funding Information: Received 28 December 2005; accepted 20 May 2006. Supported by a grant from the Gatorade Sports Science Institute. We acknowledge the skillful assistance of Nathaniel Bailey, Jessica Eaton, and Kevin Oley in this research project. Address correspondence to David C. Nieman, DrPH, FACSM, Department of Health, Leisure, & Exercise Science, P.O. Box 32071, Appalachian State University, Boone, NC 28608, USA. E-mail: [email protected]

PY - 2006/9/1

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N2 - The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64% Wattsmax while receiving 4 mL·kg-1·15 min-1 carbohydrate (6%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.

AB - The influence of carbohydrate compared with placebo ingestion on changes in immune cell counts and functions following 2 h intensive cycling was studied in 12 trained cyclists who functioned as their own controls. The subjects performed two tests 2 weeks apart where they cycled for 2 h at ∼64% Wattsmax while receiving 4 mL·kg-1·15 min-1 carbohydrate (6%) (Cho) or placebo (Pla) beverages. Blood samples were collected 30 min preexercise, and immediately and 1 h postexercise. The samples were assayed for plasma cortisol and epinephrine, blood leukocyte subset counts, PHA-induced lymphocyte proliferation, and natural killer cell activity (NKCA). Compared with Pla ingestion, Cho attenuated exercise-induced changes in plasma cortisol, blood neutrophil, and monocyte counts, but not in total blood lymphocyte, T cell, and NK cell counts, PHA-induced lymphocyte proliferation, and NKCA. Thus despite a strong attenuating influence of carbohydrate ingestion on exercise-induced changes in plasma cortisol and blood neutrophil and monocyte counts, other immune measures related to lymphocyte subset counts, and function were unaffected.

KW - Exercise

KW - Lymphocytes

KW - Natural killer cells

KW - T cells

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ER -

Influence of carbohydrate on immune function following 2 h cycling

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