Innovative optofluidics and microscopy-based rapid analysis of pathogens

Hao Wang, Priyanka Shiveshwarkar, Robert Brzozowski, Arseny Zhdanov, Shulin Shi, Prahathees Eswara, Anna Pyayt

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The timely knowledge and prescription of the most suitable antibiotic to treat bacterial infections is critical for the recovery of patients battling life-threatening bacterial infections. Unfortunately, current standard-of-care approaches relies on the empiric prescription of an antibiotic, as determination of the most effective antibiotic requires multiple time-consuming steps. These steps often include culturing of the bacterium responsible for infection and subsequent antibiotic susceptibility testing. Here we introduce an optofluidic technology that allows us to capture bacterial cells efficiently and rapidly from different biological samples and use the captured cells for rapid antibiotic selection thereby bypassing the need to culture the bacterium.

Original languageEnglish
Pages (from-to)5060-5069
Number of pages10
JournalBiomedical Optics Express
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2020

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