Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine

J. H. Nunberg; M. V. Doyle; S. M. York; C. J. York

doi:10.1073/pnas.86.11.4240

Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine

J. H. Nunberg, M. V. Doyle, S. M. York, C. J. York

Montana Biotechnology Center

Novartis

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic administration of IL-2 in conjunction with inactivated rabies virus can increase the potency of vaccination in outbred mice at least 25-fold, as measured by survival following challenge with virulent rabies virus. Enhanced protection is not correlated with an increase in virus-neutralizing antibody titers, and we suggest that IL-2 acts to increase the cellular immune response to vaccination.

Original language	English
Pages (from-to)	4240-4243
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	86
Issue number	11
DOIs	https://doi.org/10.1073/pnas.86.11.4240
State	Published - 1989

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title = "Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine",

abstract = "Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic administration of IL-2 in conjunction with inactivated rabies virus can increase the potency of vaccination in outbred mice at least 25-fold, as measured by survival following challenge with virulent rabies virus. Enhanced protection is not correlated with an increase in virus-neutralizing antibody titers, and we suggest that IL-2 acts to increase the cellular immune response to vaccination.",

author = "Nunberg, {J. H.} and Doyle, {M. V.} and York, {S. M.} and York, {C. J.}",

note = "Funding Information: Financial support by PRH-28/ANP/PETROBRAS, FINEP, RECAT, CETENE and INCT-EMA. The English version was revised by Sidney Pratt, Canadian, BA, MAT (The Johns Hopkins University), RSAdip (TEFL) (Cambridge University).",

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AU - Doyle, M. V.

AU - York, S. M.

AU - York, C. J.

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AB - Interleukin 2 (IL-2) occupies a central position in the cascade of events involved in the immune response. We were interested in determining whether IL-2 could function as an adjuvant to vaccination, to increase the immune response to vaccine immunogens. Using the National Institutes of Health test for rabies vaccine potency, we found that daily systemic administration of IL-2 in conjunction with inactivated rabies virus can increase the potency of vaccination in outbred mice at least 25-fold, as measured by survival following challenge with virulent rabies virus. Enhanced protection is not correlated with an increase in virus-neutralizing antibody titers, and we suggest that IL-2 acts to increase the cellular immune response to vaccination.

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Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine

Abstract

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