Isolation and Structure Determination of the Second Toxic Constituent from Tetradymia glabrata

Paul W. Jennings, Jerome C. Hurley, S. K. Reeder, Andrij Holian, Pauthon Lee, Charles N. Caughlan, Raymond D. Larsen

Research output: Contribution to journalArticlepeer-review

Abstract

A new furanoeremophilane has been isolated and a derivative of it analyzed by x-ray crystallography. The two compounds are 10β-hydroxy-6β-isobutyrylfuranoeremophilane (II) and 6β,10β-dihydroxyfuranoeremophilane (III). Both have been shown to be hepatotoxins, LD50IP400 and 113 mg/kg, respectively. Physical data are included in the publication with particular emphasis on NMR spectra correlation with x-ray structure. Compound III crystallized in a space group P212121 with cell dimensions a = 21.322 (7) Å,b = 7.593 (2) Å,c= 8.387 (1) Å, with Z = 4. Counter data were refined by full-matrix least squares to a residual of 4.7%.

Original languageEnglish
Pages (from-to)4078-4081
Number of pages4
JournalJournal of Organic Chemistry
Volume41
Issue number26
DOIs
StatePublished - Dec 1 1976

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