Isolation of two highly methylated polyketide derivatives from a yew- associated Penicillium species

Donald B. Stierle; Andrea A. Stierle; Barbie K. Ganser

doi:10.1021/np980510v

Isolation of two highly methylated polyketide derivatives from a yew- associated Penicillium species

Donald B. Stierle, Andrea A. Stierle, Barbie K. Ganser

University of Montana

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both compounds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.

Original language	English
Pages (from-to)	1147-1150
Number of pages	4
Journal	Journal of Natural Products
Volume	62
Issue number	8
DOIs	https://doi.org/10.1021/np980510v
State	Published - Aug 1999

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title = "Isolation of two highly methylated polyketide derivatives from a yew- associated Penicillium species",

abstract = "Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both compounds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.",

author = "Stierle, {Donald B.} and Stierle, {Andrea A.} and Ganser, {Barbie K.}",

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AB - Two selective antifungal agents were produced by a Penicillium sp. isolated from the inner bark of the Pacific yew tree, Taxus brevifolia. The structures of these highly methylated polyketide derivatives were deduced by detailed analysis of both 1D and 2D NMR and difference NOE spectra. Both compounds were active against the plant pathogen, Sclerotinia sclerotiorum in the standard disk assay.

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Isolation of two highly methylated polyketide derivatives from a yew- associated Penicillium species

Abstract

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