Kimbasines A and B, novel hexacyclic norsesterterpene alkaloids from the sponge Igernella notabilis

John H. Cardellina; Robert L. Hendrickson; Andrea A. Stierle; Gary E. Martin

doi:10.1016/S0040-4039(00)79920-5

Kimbasines A and B, novel hexacyclic norsesterterpene alkaloids from the sponge Igernella notabilis

John H. Cardellina, Robert L. Hendrickson, Andrea A. Stierle, Gary E. Martin

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Abstract

Two novel hexacyclic norsesterterpene alkaloids, kimbasines A and B, have been isolated from cytotoxic extracts of the sponge Igernella notabilis. The structures, related as butyrate and acetate esters, were solved by analyses of spectral data of kimbasine A and comparison of data for kimbasine B with those of kimbasine A. Biological testing data for kimbasine A are presented.

Original language	English
Pages (from-to)	2347-2350
Number of pages	4
Journal	Tetrahedron Letters
Volume	32
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(00)79920-5
State	Published - May 20 1991

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title = "Kimbasines A and B, novel hexacyclic norsesterterpene alkaloids from the sponge Igernella notabilis",

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author = "Cardellina, {John H.} and Hendrickson, {Robert L.} and Stierle, {Andrea A.} and Martin, {Gary E.}",

note = "Funding Information: by the National Cancer Institute, the Sea Grant Program (Department",

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T1 - Kimbasines A and B, novel hexacyclic norsesterterpene alkaloids from the sponge Igernella notabilis

AU - Cardellina, John H.

AU - Hendrickson, Robert L.

AU - Stierle, Andrea A.

AU - Martin, Gary E.

N1 - Funding Information: by the National Cancer Institute, the Sea Grant Program (Department

PY - 1991/5/20

Y1 - 1991/5/20

N2 - Two novel hexacyclic norsesterterpene alkaloids, kimbasines A and B, have been isolated from cytotoxic extracts of the sponge Igernella notabilis. The structures, related as butyrate and acetate esters, were solved by analyses of spectral data of kimbasine A and comparison of data for kimbasine B with those of kimbasine A. Biological testing data for kimbasine A are presented.

AB - Two novel hexacyclic norsesterterpene alkaloids, kimbasines A and B, have been isolated from cytotoxic extracts of the sponge Igernella notabilis. The structures, related as butyrate and acetate esters, were solved by analyses of spectral data of kimbasine A and comparison of data for kimbasine B with those of kimbasine A. Biological testing data for kimbasine A are presented.

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U2 - 10.1016/S0040-4039(00)79920-5

DO - 10.1016/S0040-4039(00)79920-5

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 21

ER -

Kimbasines A and B, novel hexacyclic norsesterterpene alkaloids from the sponge Igernella notabilis

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