Landscape Genetics for Cancer Biology

Erin L. Landguth, Norman A. Johnson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Since the early 2000s, landscape genetics has been used across many fields of ecology and evolution to study invasion dynamics of non-native species, range expansion and contraction, genetic rescue and monitoring, and eco-evolutionary dynamics. At the field’s core, landscape genetics studies landscape connectivity of genes-how individuals move genes via conduits in the environment. There are many similarities between tumor connectivity-how tumors spread-and landscape genetic connectivity-how genes spread across landscapes. In this chapter, we explore the transdisciplinary research approaches of landscape genetics and cancer biology. These areas include (1) landscape composition and structure influence on genetic patterns and processes across multiple scales for promoting/preventing successful colonization of distant individuals/tissues and (2) several techniques used in landscape genetics relevant for cancer biology questions that span creating genetic resistance landscapes, replicating pattern-process relationships to help strengthen findings, developing connectivity models for identifying key corridors of gene flow, isolating selection-driven patterns for understanding genotype by environmental relationships, and using environmental DNA to help map genetic biodiversity connections across landscapes.

Original languageEnglish
Title of host publicationCancer through the Lens of Evolution and Ecology
PublisherCRC Press
Number of pages19
ISBN (Electronic)9781040027660
ISBN (Print)9781032310787
StatePublished - May 13 2024


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