Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones

Scott A. Steiger, Chun Li, Charles F. Campana, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

The Ytterbium (III) triflate catalyzed Hantzsch synthesis allows for the preparation of sterically hindered 4-isoxazolyl-1,4-dihydropyridines in moderate to good yields. Asymmetric organocatalysis with (R)-4-Oxo-2,6-bis-(2,4,6-triisopropyl-phenyl)-3,5-dioxa-4l5-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-ol (R-TRIP) produces moderate yields of chiral 4-isoxazolyl-quinolones with high enantioselectivity.

Original languageEnglish
Pages (from-to)423-425
Number of pages3
JournalTetrahedron Letters
Volume57
Issue number3
DOIs
StatePublished - Jan 20 2016

Keywords

  • Asymmetric organocatalysis
  • Dihydropyridine
  • Isoxazole
  • Lanthanide catalysis
  • Quinolone

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