Abstract
The larynx plays a key role in airway protection via the laryngeal chemoreflex (LCR).This involuntary reflex can be evoked when hazardous substances activate mucosal receptors, which send signals to be processed within the brainstem. Although the LCR is meant to be protective, the reflex can become hyperstimulated, even to benign stimuli, which can result in pathological disorders, such as chronic cough and inducible laryngeal obstruction. In this review, we will outline the mechanism of the LCR and its associated pathological disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 823-831 |
| Number of pages | 9 |
| Journal | Chemical Senses |
| Volume | 45 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 1 2020 |
Funding
This work was supported by the National Institute on Deafness and other Communication Disorders, at the National Institutes of Health [grant numbers T32DC012280 and K23DC014747]. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
| Funder number |
|---|
| T32DC012280, K23DC014747 |
Keywords
- Airway receptors
- Chemoreflex
- Cough
- Larynx