@article{5c54ea09588a4c25ac5fc80c6f58168d,
title = "Leukotriene B4 stimulation of phosphatidylinositol turnover in macrophages and inhibition by pertussis toxin",
abstract = "The influence of leukotriene B4 (LTB4) on phosphatidylinositol (PI) cycle activity was investigated in the guinea pig alveolar macrophage. In contrast to the observation reported in leukocytes [(1984) Proc. Natl. Acad. Sci. USA 81, 5966-5969], LTB4 was found to stimulate PI cycle activity in the macrophage (transient decrease in phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate, transient elevation of 1,2-diacylglycerol and elevation of phosphatidic acid) similar to the stimulation of the PI cycle by the chemotactic formyi peptides. Preincubation of macrophages with 1 μ/ml of pertussis toxin, for 1 h at 37°C, blocked LTB4 and formyl peptide stimulated O2- production and PI cycle activity. Therefore, both stimulants are proposed to act through the same coupling protein to activate phospholipase C in the early stages of macrophage activation.",
keywords = "Formyl peptide, Leukotriene B, Macrophage, Pertussis toxin, Phosphatidylinositol",
author = "Andrij Holian",
year = "1986",
month = may,
day = "26",
doi = "10.1016/0014-5793(86)80562-2",
language = "English",
volume = "201",
pages = "15--19",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "1",
}