Manufacturability of a Tetraethyl Orthosilicate-Based Hydrogel for Use as a Single Application Otitis Externa Therapeutic

Emma Barrett-Catton, Elizabeth M. Arrigali, Bogdan A. Serban, Kolton C. Sandau, Monica A. Serban

Research output: Contribution to journalArticlepeer-review

Abstract

Otitis externa, also known as outer ear infection, is a frequent affliction in both humans and animals. The most prevalent treatment for otitis externa is ear drops, but it is difficult to adhere properly to this treatment, causing poor patient compliance and the potential for complications. As a result, we have developed a tetraethyl orthosilicate-based hydrogel for use as single application treatment for otitis externa to increase ease of use and improve patient outcomes. Herein, we investigated the manufacturability of the hydrogel, focusing on several key aspects: formulation repeatability and reproducibility, material source and tolerances, release of a variety of model drugs, and impact of application-specific physiological factors, specifically local pH and enzymatic activity on drug release. Overall, our results indicate that these hydrogels are well suited for production and scalability, as they have a robust manufacturing process, have a wide tolerance for pH level, release a variety of model drugs, and are not impacted by outer ear canal-specific physiological factors.

Original languageEnglish
Article number2020
JournalPharmaceutics
Volume14
Issue number10
DOIs
StatePublished - Oct 2022

Keywords

  • drug release
  • hyaluronan
  • hydrogel
  • manufacturing
  • nanoparticles
  • otitis externa
  • tetraethyl orthosilicate

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