TY - JOUR
T1 - Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations
AU - Ferguson, Matthew D.
AU - Semmens, Erin O.
AU - Dumke, Charles
AU - Quindry, John C.
AU - Ward, Tony J.
N1 - Publisher Copyright:
© 2016 American College of Occupational and Environmental Medicine.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Objective: A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM 2.5 on measured concentrations of airway and systemic inflammatory biomarkers. Methods: Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM 2.5 (filtered-air, 250μg/m3, and 500μg/m3) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour postexposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC, while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma. Results: Only pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre-and postexposures. Conclusions: Markers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.
AB - Objective: A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM 2.5 on measured concentrations of airway and systemic inflammatory biomarkers. Methods: Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM 2.5 (filtered-air, 250μg/m3, and 500μg/m3) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour postexposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC, while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma. Results: Only pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre-and postexposures. Conclusions: Markers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.
UR - http://www.scopus.com/inward/record.url?scp=84964528225&partnerID=8YFLogxK
U2 - 10.1097/JOM.0000000000000688
DO - 10.1097/JOM.0000000000000688
M3 - Article
C2 - 27058482
AN - SCOPUS:84964528225
SN - 1076-2752
VL - 58
SP - 407
EP - 413
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
IS - 4
ER -