Measurement of oxygen consumption on-kinetics during exercise: Implications for patients with heart failure

Ross Arena, Reed Humphrey, Mary Ann Peberdy

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Oxygen consumption (Vo2) on-kinetics describes the rate change in oxygen uptake at the initiation of exercise. Several mathematical and graphical methods are used to assess Vo2on-kinetics during constant-load or progressive exercise. Vo2on-kinetics is prolonged in patients with heart failure (HF) compared with individuals who have normal cardiopulmonary function. Cardiac function has been implicated as one of the controlling mechanism for this observation. The contribution that pulmonary, vascular, and skeletal muscle function makes to delayed Vo2on-kinetics in HF has yet to be determined. Vo2on-kinetics also appears to have clinical value in HF, although evidence supporting this claim is limited. Questions about the controlling mechanism(s) and practical application of Vo2on-kinetics in HF therefore remain unanswered. This report provides an overview of Vo2on-kinetics assessment techniques, reviews research pertaining to the HF population, and provides direction for future investigations.

    Original languageEnglish
    Pages (from-to)302-310
    Number of pages9
    JournalJournal of Cardiac Failure
    Volume7
    Issue number4
    DOIs
    StatePublished - Dec 2001

    Keywords

    • Exercise testing
    • Oxygen deficit
    • Prognosis
    • Time constant

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