Mechanical ventilators optimized for pediatric use decrease work of breathing and oxygen consumption during pressure-support ventilation

M. F. El-Khatib, R. L. Chatburn, D. L. Potts, J. L. Blumer, P. G. Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: a) To investigate whether the patient work of breathing needed to trigger inspiration is affected by the type of ventilator delivering pressure-support ventilation for mechanically ventilated pediatric patients. b) To determine whether changes in oxygen consumption (V̇O2) trend with changes in work of breathing and would thus be helpful in tracking work of breathing. Design: Prospective study. Setting: Pediatric intensive care unit at a university hospital. Patients: Nine mechanically ventilated patients (2 to 75 months of age). Interventions: While maintaining a constant pressure- support ventilation level, patients were alternately supported with the Siemens Servo 900C, the Bird VIP, and the Newport Wave E200 ventilators in random order. Measurements and Main Results: Work of breathing, defined as the integral of the pressure-volume curve corresponding to negative pressure, was calculated with a pulmonary monitoring system. V̇O2 was measured with a metabolic cart. Patient distress levels were assessed using the COMFORT scale, a behavioral scoring system. Mean values (20 breaths/patient) for measured variables with each ventilator were compared using analysis of variance and Scheffe tests, with p < .05 indicating statistical significance. The lowest V̇O2 (103 ± 35 mL/min/m2) and work of breathing (24 ± 15 g · cm/m2) were achieved with the Bird VIP ventilator and were significantly (p < .05) lower than those values obtained with either the Siemens Servo 900C (V̇O2 147 ± 33 mL/min/m2; work of breathing 49 ± 18 g · cm/m2) or the Newport Wave E200 (V̇O2 122 ± 33 mL/min/m2; work of breathing 35 ± 15 g · cm/m2). Also, the values of work of breathing and V̇O2 obtained using the Newport Wave E200 were significantly (p < .05) lower than those values obtained using the Servo 900C. No change in behavioral distress occurred when the ventilators were changed. In all patients, there was a clear similarity in the trends of V̇O2 and work of breathing. Conclusions: We conclude that V̇O2 and work of breathing may be reduced significantly using the latest generation of mechanical ventilators optimized for infant and pediatric use. Because work of breathing is less with the Bird VIP than the other two ventilators tested, leading to a corresponding decrease in V̇O2, we suggest that the Bird VIP better adapts the patient to the ventilator and may facilitate weaning from ventilatory support. We also suggest that changes in V̇O2 might be helpful in tracking changes in work of breathing.

Original languageEnglish
Pages (from-to)1942-1948
Number of pages7
JournalCritical Care Medicine
Volume22
Issue number12
DOIs
StatePublished - 1994

Keywords

  • critical illness
  • intensive care unit
  • lung
  • mechanical ventilation
  • oxygen consumption
  • pediatrics
  • pressure-support ventilation
  • ventilator weaning
  • work of breathing

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