Melatonin metabolite excretion among cellular telephone users

J. B. Burch; J. S. Reif; C. W. Noonan; T. Ichinose; A. M. Bachand; T. L. Koleber; M. G. Yost

doi:10.1080/09553000210166561

Melatonin metabolite excretion among cellular telephone users

J. B. Burch
, J. S. Reif
, C. W. Noonan
, T. Ichinose
, A. M. Bachand
, T. L. Koleber
, M. G. Yost

School of Public and Community Health Sciences

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Purpose: The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). Materials and methods: Participants collected urine samples and recorded cellular telephone use over 3 consecutive workdays. Personal 60-Hz magnetic field (MF) and ambient light exposures were characterized on the same days using EMDEX II meters. A repeated measures analysis was used to assess the effects of cellular telephone use, alone and combined with MF exposures, after adjustment for age, participation month and light exposure. Results: No change in 6-OHMS excretion was observed among those with daily cellular telephone use >25min in Study 1 (5 worker-days). Study 2 workers with >25min cellular telephone use per day (13 worker-days) had lower creatinine-adjusted mean nocturnal 6-OHMS concentrations (p=0.05) and overnight 6-OHMS excretion (p=0.03) compared with those without cellular telephone use. There was also a linear trend of decreasing mean nocturnal 6-OHMS/creatinine concentrations (p=0.02) and overnight 6-OHMS excretion (p=0.08) across categories of increasing cellular telephone use. A combined effect of cellular telephone use and occupational 60-Hz MF exposure in reducing 6-OHMS excretion was also observed in Study 2. Conclusions: Exposure-related reductions in 6-OHMS excretion were observed in Study 2, where daily cellular telephone use of >25min was more prevalent. Prolonged use of cellular telephones may lead to reduced melatonin production, and elevated 60-Hz MF exposures may potentiate the effect.

Original language	English
Pages (from-to)	1029-1036
Number of pages	8
Journal	International Journal of Radiation Biology
Volume	78
Issue number	11
DOIs	https://doi.org/10.1080/09553000210166561
State	Published - Nov 1 2002

Funding

The authors gratefully acknowledge the cooperation of the participatinugtliiiet. Usrinary 6-OHMS assays were performed under the direction of Dr Tery rNett, Director of the Radioimmunoassay Laboratory for the CSU Animal Research and Biotechnology Laboratories. The authors thank Ms Jeanette Haddock for assistance with data collection; Ms Xiaoming Sha for assistance with the 6-OHMS assay; and Drs Lee Wilke and Martin Fettman for assistance with the creatinine assays. Dr Scott Davis of the Fred Hutchinson Cancer Research Center provided the design for adaptation of the light sensors to the EMDEX meters. Battelle PaciŽ c Northwest Laboratories and Platte River Power Authority provided light meters. Mr Ken Westebr provided computer-programming assistance. This work was supported by research Grant No. 1 R01ES01781 from the National Institute of Environmental Health Sciences, National Institute of Health, USA.

Funder number
R01ES008117

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10.1080/09553000210166561

Cite this

@article{18ac4da8ca5d41afab82c997173c0a38,

title = "Melatonin metabolite excretion among cellular telephone users",

abstract = "Purpose: The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). Materials and methods: Participants collected urine samples and recorded cellular telephone use over 3 consecutive workdays. Personal 60-Hz magnetic field (MF) and ambient light exposures were characterized on the same days using EMDEX II meters. A repeated measures analysis was used to assess the effects of cellular telephone use, alone and combined with MF exposures, after adjustment for age, participation month and light exposure. Results: No change in 6-OHMS excretion was observed among those with daily cellular telephone use >25min in Study 1 (5 worker-days). Study 2 workers with >25min cellular telephone use per day (13 worker-days) had lower creatinine-adjusted mean nocturnal 6-OHMS concentrations (p=0.05) and overnight 6-OHMS excretion (p=0.03) compared with those without cellular telephone use. There was also a linear trend of decreasing mean nocturnal 6-OHMS/creatinine concentrations (p=0.02) and overnight 6-OHMS excretion (p=0.08) across categories of increasing cellular telephone use. A combined effect of cellular telephone use and occupational 60-Hz MF exposure in reducing 6-OHMS excretion was also observed in Study 2. Conclusions: Exposure-related reductions in 6-OHMS excretion were observed in Study 2, where daily cellular telephone use of >25min was more prevalent. Prolonged use of cellular telephones may lead to reduced melatonin production, and elevated 60-Hz MF exposures may potentiate the effect.",

author = "Burch, \{J. B.\} and Reif, \{J. S.\} and Noonan, \{C. W.\} and T. Ichinose and Bachand, \{A. M.\} and Koleber, \{T. L.\} and Yost, \{M. G.\}",

note = "Funding Information: The authors gratefully acknowledge the cooperation of the participatinugtliiiet. Usrinary 6-OHMS assays were performed under the direction of Dr Tery rNett, Director of the Radioimmunoassay Laboratory for the CSU Animal Research and Biotechnology Laboratories. The authors thank Ms Jeanette Haddock for assistance with data collection; Ms Xiaoming Sha for assistance with the 6-OHMS assay; and Drs Lee Wilke and Martin Fettman for assistance with the creatinine assays. Dr Scott Davis of the Fred Hutchinson Cancer Research Center provided the design for adaptation of the light sensors to the EMDEX meters. Battelle Paci{\v Z} c Northwest Laboratories and Platte River Power Authority provided light meters. Mr Ken Westebr provided computer-programming assistance. This work was supported by research Grant No. 1 R01ES01781 from the National Institute of Environmental Health Sciences, National Institute of Health, USA.",

year = "2002",

month = nov,

day = "1",

doi = "10.1080/09553000210166561",

language = "English",

volume = "78",

pages = "1029--1036",

journal = "International Journal of Radiation Biology",

issn = "0955-3002",

publisher = "Taylor and Francis Ltd.",

number = "11",

}

TY - JOUR

T1 - Melatonin metabolite excretion among cellular telephone users

AU - Burch, J. B.

AU - Reif, J. S.

AU - Noonan, C. W.

AU - Ichinose, T.

AU - Bachand, A. M.

AU - Koleber, T. L.

AU - Yost, M. G.

N1 - Funding Information: The authors gratefully acknowledge the cooperation of the participatinugtliiiet. Usrinary 6-OHMS assays were performed under the direction of Dr Tery rNett, Director of the Radioimmunoassay Laboratory for the CSU Animal Research and Biotechnology Laboratories. The authors thank Ms Jeanette Haddock for assistance with data collection; Ms Xiaoming Sha for assistance with the 6-OHMS assay; and Drs Lee Wilke and Martin Fettman for assistance with the creatinine assays. Dr Scott Davis of the Fred Hutchinson Cancer Research Center provided the design for adaptation of the light sensors to the EMDEX meters. Battelle PaciŽ c Northwest Laboratories and Platte River Power Authority provided light meters. Mr Ken Westebr provided computer-programming assistance. This work was supported by research Grant No. 1 R01ES01781 from the National Institute of Environmental Health Sciences, National Institute of Health, USA.

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Purpose: The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). Materials and methods: Participants collected urine samples and recorded cellular telephone use over 3 consecutive workdays. Personal 60-Hz magnetic field (MF) and ambient light exposures were characterized on the same days using EMDEX II meters. A repeated measures analysis was used to assess the effects of cellular telephone use, alone and combined with MF exposures, after adjustment for age, participation month and light exposure. Results: No change in 6-OHMS excretion was observed among those with daily cellular telephone use >25min in Study 1 (5 worker-days). Study 2 workers with >25min cellular telephone use per day (13 worker-days) had lower creatinine-adjusted mean nocturnal 6-OHMS concentrations (p=0.05) and overnight 6-OHMS excretion (p=0.03) compared with those without cellular telephone use. There was also a linear trend of decreasing mean nocturnal 6-OHMS/creatinine concentrations (p=0.02) and overnight 6-OHMS excretion (p=0.08) across categories of increasing cellular telephone use. A combined effect of cellular telephone use and occupational 60-Hz MF exposure in reducing 6-OHMS excretion was also observed in Study 2. Conclusions: Exposure-related reductions in 6-OHMS excretion were observed in Study 2, where daily cellular telephone use of >25min was more prevalent. Prolonged use of cellular telephones may lead to reduced melatonin production, and elevated 60-Hz MF exposures may potentiate the effect.

AB - Purpose: The relationship between cellular telephone use and excretion of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) was evaluated in two populations of male electric utility workers (Study 1, n=149; Study 2, n=77). Materials and methods: Participants collected urine samples and recorded cellular telephone use over 3 consecutive workdays. Personal 60-Hz magnetic field (MF) and ambient light exposures were characterized on the same days using EMDEX II meters. A repeated measures analysis was used to assess the effects of cellular telephone use, alone and combined with MF exposures, after adjustment for age, participation month and light exposure. Results: No change in 6-OHMS excretion was observed among those with daily cellular telephone use >25min in Study 1 (5 worker-days). Study 2 workers with >25min cellular telephone use per day (13 worker-days) had lower creatinine-adjusted mean nocturnal 6-OHMS concentrations (p=0.05) and overnight 6-OHMS excretion (p=0.03) compared with those without cellular telephone use. There was also a linear trend of decreasing mean nocturnal 6-OHMS/creatinine concentrations (p=0.02) and overnight 6-OHMS excretion (p=0.08) across categories of increasing cellular telephone use. A combined effect of cellular telephone use and occupational 60-Hz MF exposure in reducing 6-OHMS excretion was also observed in Study 2. Conclusions: Exposure-related reductions in 6-OHMS excretion were observed in Study 2, where daily cellular telephone use of >25min was more prevalent. Prolonged use of cellular telephones may lead to reduced melatonin production, and elevated 60-Hz MF exposures may potentiate the effect.

UR - https://www.scopus.com/pages/publications/0036849111

U2 - 10.1080/09553000210166561

DO - 10.1080/09553000210166561

M3 - Article

C2 - 12456290

AN - SCOPUS:0036849111

SN - 0955-3002

VL - 78

SP - 1029

EP - 1036

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

IS - 11

ER -

Melatonin metabolite excretion among cellular telephone users

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