Microviscosity and enzyme-ligand dissociation

Scott L. Whittenburg

doi:10.1016/0022-5193(83)90329-6

Microviscosity and enzyme-ligand dissociation

Scott L. Whittenburg

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Abstract

The effect of viscosity on the rate constant for the dissociation of an enzyme-ligand complex has been calculated from a microscopic theory. Using the Kubo representation for the rate constant and the second quantization formalism a Stokes-Einstein-Debye expression is obtained. A microscopic expression for the viscosity is derived. The equation for the microviscosity shows how important information on the enzyme-ligand complex can be obtained from studies on the viscosity dependence of the dissociation rate constant.

Original language	English
Pages (from-to)	675-683
Number of pages	9
Journal	Journal of Theoretical Biology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/0022-5193(83)90329-6
State	Published - Feb 21 1983

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10.1016/0022-5193(83)90329-6

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title = "Microviscosity and enzyme-ligand dissociation",

abstract = "The effect of viscosity on the rate constant for the dissociation of an enzyme-ligand complex has been calculated from a microscopic theory. Using the Kubo representation for the rate constant and the second quantization formalism a Stokes-Einstein-Debye expression is obtained. A microscopic expression for the viscosity is derived. The equation for the microviscosity shows how important information on the enzyme-ligand complex can be obtained from studies on the viscosity dependence of the dissociation rate constant.",

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N2 - The effect of viscosity on the rate constant for the dissociation of an enzyme-ligand complex has been calculated from a microscopic theory. Using the Kubo representation for the rate constant and the second quantization formalism a Stokes-Einstein-Debye expression is obtained. A microscopic expression for the viscosity is derived. The equation for the microviscosity shows how important information on the enzyme-ligand complex can be obtained from studies on the viscosity dependence of the dissociation rate constant.

AB - The effect of viscosity on the rate constant for the dissociation of an enzyme-ligand complex has been calculated from a microscopic theory. Using the Kubo representation for the rate constant and the second quantization formalism a Stokes-Einstein-Debye expression is obtained. A microscopic expression for the viscosity is derived. The equation for the microviscosity shows how important information on the enzyme-ligand complex can be obtained from studies on the viscosity dependence of the dissociation rate constant.

UR - http://www.scopus.com/inward/record.url?scp=49049124424&partnerID=8YFLogxK

U2 - 10.1016/0022-5193(83)90329-6

DO - 10.1016/0022-5193(83)90329-6

M3 - Article

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VL - 100

SP - 675

EP - 683

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 4

ER -

Microviscosity and enzyme-ligand dissociation

Abstract

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