@article{de761170b2f2494d8c8f432999989ced,
title = "Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc-rter: Initial homology model",
abstract = "Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.",
keywords = "Cystine, Glutamate, Isoxazole, Microwave, Transporter",
author = "Matti, {Afnan A.} and Joseph Mirzaei and John Rudolph and Smith, {Stephen A.} and Newell, {Jayme L.} and Patel, {Sarjubhai A.} and Braden, {Michael R.} and Bridges, {Richard J.} and Natale, {Nicholas R.}",
note = "Funding Information: This work was supported in part by NIH NINDS Grants R21NS067466 (R.B. and N.N.) and P30-NS055022 (J.M. and N.N.). Modeling was carried out in the COBRE supported Molecular Computational Core facility with support from P20RR015583 and NIGMS P20GM103546 (M.B.). L.M. thanks Professor Sandy Ross of the University of Montana Graduate School for a graduate teaching assistantship. J.R. and S.A.S. acknowledge the support of the Neuroscience NSF REU at the University of Idaho . ",
year = "2013",
month = nov,
day = "1",
doi = "10.1016/j.bmcl.2013.08.080",
language = "English",
volume = "23",
pages = "5931--5935",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd",
number = "21",
}