Muscle-fiber type and blood oxidative stress after eccentric exercise

John Quindry, Lindsey Miller, Graham McGinnis, Megan Irwin, Charles Dumke, Meir Magal, N. Travis Triplett, Jeffrey McBride, Zea Urbiztondo

Research output: Contribution to journalArticlepeer-review

Abstract

Acute strength exercise elicits a transient oxidative stress, but the factors underlying the magnitude of this response remain unknown. The purpose of this investigation was to determine whether muscle-fiber type relates to the magnitude of blood oxidative stress after eccentric muscle activity. Eleven college-age men performed 3 sets of 50 eccentric knee-extensions. Blood samples taken pre-, post-, and 24, 48, 72, and 96 hr postexercise were assayed for comparison of muscle damage and oxidative-stress biomarkers including protein carbonyls (PCs). Vastus lateralis muscle biopsies were assayed for relative percentage of slow- and fast-twitch muscle fibers. There was a mixed fiber composition (Type I = 39.6% ± 4.5%, Type IIa = 35.7% ± 3.5%, Type IIx = 24.8% ± 3.8%; p = .366). PCs were elevated 24, 48, and 72 hr (p = .032) postexercise, with a peak response of 126% (p = .012) above baseline, whereas other oxidative-stress biomarkers were unchanged. There are correlations between Type II muscle-fiber type and postexercise PC. Further study is needed to understand the mechanisms responsible for the observed fast-twitch muscle-fiber oxidative-stress relationship.

Original languageEnglish
Pages (from-to)462-470
Number of pages9
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Volume21
Issue number6
DOIs
StatePublished - Dec 2011

Keywords

  • Antioxidant capacity
  • Free radicals
  • Protein carbonyls
  • Reactive oxygen species

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