Natural feedstocks for diversity-oriented synthesis: Macrolide-like scaffolds from nonactate

Yuliya G. Sumskaya, P. Whitney Swain, Stepehen C. Bergmeier, Mark C. McMills, Nigel D. Priestley, Dennis L. Wrighta

Research output: Contribution to journalArticlepeer-review

Abstract

We have been interested in the application of readily available, fermentation-derived natural products as key building blocks for the preparation of natural product-like libraries rich in structural and stereochemical diversity. In this manuscript we describe the conversion of methyl nonactate, derived from nonactin, to a diversable scaffold characteristic of macrolide natural products. The synthesis features a key ring-closing metathesis reaction to form the macrocycle.

Original languageEnglish
Pages (from-to)144-166
Number of pages23
JournalArkivoc
Volume2011
Issue number5
DOIs
StatePublished - Jan 17 2011

Keywords

  • Macrolide
  • Natural products
  • Nonactin
  • Ring-closing metathesis

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