Natural Killer Cells

David Shepherd

doi:10.1007/978-3-642-54596-2_1058

Natural Killer Cells

David Shepherd

Biomedical and Pharmaceutical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Natural killer (NK) cells are lymphoid-derived cellular components of the innate immune system. These cells are part of the first line of defense that function to contain viral infections as well as the spread of tumor cells. The measurement of NK cell activity has recently become a critical assay used to identify potentially immunotoxic chemicals. Characteristics NK cells are derived from the bone marrow and comprise approximately 5-15 % of human peripheral blood lymphocytes (Janeway et al. 2001). They lack surface expression of antigen-specific receptors, as well as many of the surface molecules such as CD3, CD4, CD8, or CD19, that are typically found on B and T lymphocytes. NK cells contain large cytoplasmic granules that aid in the killing of pathogen-infected cells, tumor cells, and major histocompatibility complex (MHC) class 1 disparate cells. However, recognition and killing of target cells by NK cells is intricately regulated by a combination of….

Original language	English
Title of host publication	Encyclopedia of Immunotoxicology
Subtitle of host publication	Second Edition
Publisher	Springer Berlin Heidelberg
Pages	654-656
Number of pages	3
ISBN (Electronic)	9783642545962
ISBN (Print)	9783642545955
DOIs	https://doi.org/10.1007/978-3-642-54596-2_1058
State	Published - Jan 1 2015

Keywords

NK cells

Access to Document

10.1007/978-3-642-54596-2_1058

Cite this

@inbook{8be5abe54a12450fbd05c6c7569fd827,

title = "Natural Killer Cells",

abstract = "Natural killer (NK) cells are lymphoid-derived cellular components of the innate immune system. These cells are part of the first line of defense that function to contain viral infections as well as the spread of tumor cells. The measurement of NK cell activity has recently become a critical assay used to identify potentially immunotoxic chemicals. Characteristics NK cells are derived from the bone marrow and comprise approximately 5-15 \% of human peripheral blood lymphocytes (Janeway et al. 2001). They lack surface expression of antigen-specific receptors, as well as many of the surface molecules such as CD3, CD4, CD8, or CD19, that are typically found on B and T lymphocytes. NK cells contain large cytoplasmic granules that aid in the killing of pathogen-infected cells, tumor cells, and major histocompatibility complex (MHC) class 1 disparate cells. However, recognition and killing of target cells by NK cells is intricately regulated by a combination of….",

keywords = "NK cells",

author = "David Shepherd",

note = "Publisher Copyright: {\textcopyright} Springer-Verlag Berlin Heidelberg 2005, 2016.",

year = "2015",

month = jan,

day = "1",

doi = "10.1007/978-3-642-54596-2\_1058",

language = "English",

isbn = "9783642545955",

pages = "654--656",

booktitle = "Encyclopedia of Immunotoxicology",

publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - Natural Killer Cells

AU - Shepherd, David

N1 - Publisher Copyright: © Springer-Verlag Berlin Heidelberg 2005, 2016.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Natural killer (NK) cells are lymphoid-derived cellular components of the innate immune system. These cells are part of the first line of defense that function to contain viral infections as well as the spread of tumor cells. The measurement of NK cell activity has recently become a critical assay used to identify potentially immunotoxic chemicals. Characteristics NK cells are derived from the bone marrow and comprise approximately 5-15 % of human peripheral blood lymphocytes (Janeway et al. 2001). They lack surface expression of antigen-specific receptors, as well as many of the surface molecules such as CD3, CD4, CD8, or CD19, that are typically found on B and T lymphocytes. NK cells contain large cytoplasmic granules that aid in the killing of pathogen-infected cells, tumor cells, and major histocompatibility complex (MHC) class 1 disparate cells. However, recognition and killing of target cells by NK cells is intricately regulated by a combination of….

AB - Natural killer (NK) cells are lymphoid-derived cellular components of the innate immune system. These cells are part of the first line of defense that function to contain viral infections as well as the spread of tumor cells. The measurement of NK cell activity has recently become a critical assay used to identify potentially immunotoxic chemicals. Characteristics NK cells are derived from the bone marrow and comprise approximately 5-15 % of human peripheral blood lymphocytes (Janeway et al. 2001). They lack surface expression of antigen-specific receptors, as well as many of the surface molecules such as CD3, CD4, CD8, or CD19, that are typically found on B and T lymphocytes. NK cells contain large cytoplasmic granules that aid in the killing of pathogen-infected cells, tumor cells, and major histocompatibility complex (MHC) class 1 disparate cells. However, recognition and killing of target cells by NK cells is intricately regulated by a combination of….

KW - NK cells

UR - https://www.scopus.com/pages/publications/105010455007

U2 - 10.1007/978-3-642-54596-2_1058

DO - 10.1007/978-3-642-54596-2_1058

M3 - Chapter

AN - SCOPUS:105010455007

SN - 9783642545955

SP - 654

EP - 656

BT - Encyclopedia of Immunotoxicology

PB - Springer Berlin Heidelberg

ER -

Natural Killer Cells

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this