Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis

Joshua B. Phillips, Adrienne E. Smith, Brian R. Kusche, Bradley A. Bessette, P. Whitney Swain, Stephen C. Bergmeier, Mark C. McMills, Dennis L. Wright, Nigel D. Priestley

Research output: Contribution to journalArticlepeer-review

Abstract

We have shown that the intentional engineering of a natural product biosynthesis pathway is a useful way to generate stereochemically complex scaffolds for use in the generation of combinatorial libraries that capture the structural features of both natural products and synthetic compounds. Analysis of a prototype library based upon nonactic acid lead to the discovery of triazole-containing nonactic acid analogs, a new structural class of antibiotic that exhibits bactericidal activity against drug resistant, Gram-positive pathogens including Staphylococcus aureus and Enterococcus faecalis.

Original languageEnglish
Pages (from-to)5936-5938
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number19
DOIs
StatePublished - Oct 1 2010

Keywords

  • Antibiotic
  • Biosynthesis
  • Nonactin
  • Triazoloester

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