Nebulized morphine for relief of dyspnea due to chronic lung disease

Sherrill J. Brown, Samantha F. Eichner, Jennifer R. Jones

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


OBJECTIVE: To evaluate the efficacy and safety of nebulized morphine for the management of dyspnea in chronic pulmonary diseases. DATA SOURCES: MEDLINE (1966-May 2004), EMBASE (1980-May 2004), and International Pharmaceutical Abstracts (1970-May 2004) searches were performed. Key search terms included morphine, dyspnea, and inhalation. DATA SYNTHESIS: Nine studies have evaluated the efficacy of nebulized morphine in relieving dyspnea. Three trials had positive resuts, but the rest failed to show improvement after treatment with doses ranging from 1 to 40 mg nebulized morphine. The small number of subjects, variety of disease states, and different outcome measures limit interpretation of the studies. CONCLUSIONS: Results from several small studies do not support the use of nebulized morphine for treatment of dyspnea; however, several positive case reports have been published.

Original languageEnglish
Pages (from-to)1088-1092
Number of pages5
JournalAnnals of Pharmacotherapy
Issue number6
StatePublished - Jun 2005


  • Dyspnea
  • Morphine
  • Nebulization


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