Nonactin biosynthesis: The product of the resistance gene degrades nonactin stereospecifically to form homochiral nonactate dimers

James E. Cox, Nigel D. Priestley

Research output: Contribution to journalArticlepeer-review

Abstract

Heterologous expression of the tetranactin resistance gene nonR in E. coli gave a his6-tagged protein that catalyzed the stereoselective hydrolysis of the chiral macrotetrolide antibiotic nonactin into equivalent, chiral, inactive nonactate dimer species. No trimeric nonactate was produced in the reaction.

Original languageEnglish
Pages (from-to)7976-7977
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number22
DOIs
StatePublished - Jun 8 2005

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