Nucleophilic aromatic substitution with the anion of 3,5‐disubstituted isoxazole‐4‐carboxylic acids

Michael D. Mosher, Nicholas R. Natale

Research output: Contribution to journalArticlepeer-review

Abstract

The preparation of the anion of a series of protected 3,5‐disubstituted 4‐isoxazolecarboxylic acids and the resulting addition of the anion to 9‐chloroacridine is described. The addition‐elimination reaction proceeds to give the expected acridinylmethylisoxazoles and has been justified based on calculated molecular mechanics energies and solvent effects.

Original languageEnglish
Pages (from-to)1385-1387
Number of pages3
JournalJournal of Heterocyclic Chemistry
Volume32
Issue number4
DOIs
StatePublished - 1995

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