TY - JOUR
T1 - parC mutations in fluoroquinolone-resistant Borrelia burgdorferi
AU - Galbraith, Kendal M.
AU - Ng, Amanda C.
AU - Eggers, Betsy J.
AU - Kuchel, Craig R.
AU - Eggers, Christian H.
AU - Samuels, D. Scott
PY - 2005/10
Y1 - 2005/10
N2 - We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
AB - We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.
UR - http://www.scopus.com/inward/record.url?scp=25844514315&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.10.4354-4357.2005
DO - 10.1128/AAC.49.10.4354-4357.2005
M3 - Article
C2 - 16189120
AN - SCOPUS:25844514315
SN - 0066-4804
VL - 49
SP - 4354
EP - 4357
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 10
ER -
