parC mutations in fluoroquinolone-resistant Borrelia burgdorferi

Kendal M. Galbraith, Amanda C. Ng, Betsy J. Eggers, Craig R. Kuchel, Christian H. Eggers, D. Scott Samuels

Research output: Contribution to journalArticlepeer-review

Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

Original languageEnglish
Pages (from-to)4354-4357
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number10
DOIs
StatePublished - Oct 2005

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