parC mutations in fluoroquinolone-resistant Borrelia burgdorferi

Kendal M. Galbraith; Amanda C. Ng; Betsy J. Eggers; Craig R. Kuchel; Christian H. Eggers; D. Scott Samuels

doi:10.1128/AAC.49.10.4354-4357.2005

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi

Kendal M. Galbraith
, Amanda C. Ng
, Betsy J. Eggers
, Craig R. Kuchel
, Christian H. Eggers
, D. Scott Samuels

Division of Biological and Biomedical Sciences

University of Montana
University of Wisconsin-Madison
Bristol-Myers Squibb
University of Connecticut

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

Original language	English
Pages (from-to)	4354-4357
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	10
DOIs	https://doi.org/10.1128/AAC.49.10.4354-4357.2005
State	Published - Oct 2005

Funding

Funder number
R01AI051486

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1128/AAC.49.10.4354-4357.2005

Cite this

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title = "parC mutations in fluoroquinolone-resistant Borrelia burgdorferi",

abstract = "We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.",

author = "Galbraith, \{Kendal M.\} and Ng, \{Amanda C.\} and Eggers, \{Betsy J.\} and Kuchel, \{Craig R.\} and Eggers, \{Christian H.\} and Samuels, \{D. Scott\}",

year = "2005",

month = oct,

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language = "English",

volume = "49",

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journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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TY - JOUR

T1 - parC mutations in fluoroquinolone-resistant Borrelia burgdorferi

AU - Galbraith, Kendal M.

AU - Ng, Amanda C.

AU - Eggers, Betsy J.

AU - Kuchel, Craig R.

AU - Eggers, Christian H.

AU - Samuels, D. Scott

PY - 2005/10

Y1 - 2005/10

N2 - We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

AB - We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

UR - https://www.scopus.com/pages/publications/25844514315

U2 - 10.1128/AAC.49.10.4354-4357.2005

DO - 10.1128/AAC.49.10.4354-4357.2005

M3 - Article

C2 - 16189120

AN - SCOPUS:25844514315

SN - 0066-4804

VL - 49

SP - 4354

EP - 4357

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

ER -

parC mutations in fluoroquinolone-resistant Borrelia burgdorferi

Abstract

Funding

UN SDGs

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