Partial agonists and subunit selectivity at NMDA receptors

Rune Risgaard, Kasper B. Hansen, Rasmus P. Clausen

Research output: Contribution to journalReview articlepeer-review

Abstract

Subunit-selective ligands for glutamate receptors remains an area of interest as glutamate is the major excitatory neurotransmitter in the brain and involved in a number of diseased states in the central nervous system (CNS). Few subtype-selective ligands are known, especially among the N-methyl-D-aspartic acid (NMDA) receptor class. Development of these ligands seems to be a difficult task because of the conserved region in the binding site of the NMDA receptor subunits. A few scaffolds have been developed showing potential to differentiate between the NMDA receptors.

Original languageEnglish
Pages (from-to)13910-13918
Number of pages9
JournalChemistry - A European Journal
Volume16
Issue number47
DOIs
StatePublished - Dec 17 2010

Keywords

  • agonists
  • glutamate
  • ligand design
  • receptors
  • subunit selectivity

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