TY - JOUR
T1 - Pharmacokinetic variations of nimesulide in mongrel dogs according to age
AU - Guillé, Pérez G.
AU - Guillé, Pérez B.E.
AU - Espinosa, Rivera L.
AU - Juárez-Olguín, H.
AU - Álvarez, García R.
AU - Brisuela, Osnaya N.
AU - Portugal, Carrasco M.
AU - Garcidueñas, Calderón L.
AU - Rosales, Soriano R.E.
AU - Luna, Jiménez Bravo M.A.
AU - Medina, Alemón R.
AU - Pacheco, Chávez J.L.
N1 - Publisher Copyright:
© 2019 Avoxa – Mediengruppe Deutscher Apotheker GmbH. All rights reserved.
PY - 2019/12
Y1 - 2019/12
N2 - The purpose of this research was to investigate the possible variations to the pharmacokinetics of nimesulide by the effect of age using an animal model. An experimental, analytical, prospective and longitudinal study in five dogs, from birth to 730 days of age was carried out. Nimesulide blood levels were measured in different months; concentrations were determined by HPLC-UV. Pharmacokinetic parameters were calculated by using the WinNonlin software. There were statistically significant differences (p <0.05) in most of the pharmacokinetic parameters between study of 6 months against the other three studies in different ages. Changes in the pharmacokinetic parameters of nimesulide as a result of age, are determined by the growing and maturation of the animals. Resulting data suggest that nimesulide can be used safely as a long-term analgesic in dogs, but, the dosing regimens in humans should be different when administered at early age.
AB - The purpose of this research was to investigate the possible variations to the pharmacokinetics of nimesulide by the effect of age using an animal model. An experimental, analytical, prospective and longitudinal study in five dogs, from birth to 730 days of age was carried out. Nimesulide blood levels were measured in different months; concentrations were determined by HPLC-UV. Pharmacokinetic parameters were calculated by using the WinNonlin software. There were statistically significant differences (p <0.05) in most of the pharmacokinetic parameters between study of 6 months against the other three studies in different ages. Changes in the pharmacokinetic parameters of nimesulide as a result of age, are determined by the growing and maturation of the animals. Resulting data suggest that nimesulide can be used safely as a long-term analgesic in dogs, but, the dosing regimens in humans should be different when administered at early age.
UR - http://www.scopus.com/inward/record.url?scp=85077631639&partnerID=8YFLogxK
U2 - 10.1691/ph.2019.9121
DO - 10.1691/ph.2019.9121
M3 - Article
C2 - 31907111
AN - SCOPUS:85077631639
SN - 0031-7144
VL - 74
SP - 728
EP - 731
JO - Pharmazie
JF - Pharmazie
IS - 12
ER -