PharmVar GeneFocus: CYP2C19

Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A.G. Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, Andrea Gaedigk

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C19 gene. CYP2C19 genetic variation impacts the metabolism of many drugs and has been associated with both efficacy and safety issues for several commonly prescribed medications. This GeneFocus provides a comprehensive overview and summary of CYP2C19 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Original languageEnglish
Pages (from-to)352-366
Number of pages15
JournalClinical Pharmacology and Therapeutics
Volume109
Issue number2
DOIs
StatePublished - Feb 2021

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