PharmVar GeneFocus: CYP2C9

Katrin Sangkuhl; Karla Claudio-Campos; Larisa H. Cavallari; Jose A.G. Agundez; Michelle Whirl-Carrillo; Jorge Duconge; Andria L. Del Tredici; Mia Wadelius; Mariana Rodrigues Botton; Erica L. Woodahl; Stuart A. Scott; Teri E. Klein; Victoria M. Pratt; Ann K. Daly; Andrea Gaedigk

doi:10.1002/cpt.2333

PharmVar GeneFocus: CYP2C9

Katrin Sangkuhl, Karla Claudio-Campos, Larisa H. Cavallari, Jose A.G. Agundez, Michelle Whirl-Carrillo, Jorge Duconge, Andria L. Del Tredici, Mia Wadelius, Mariana Rodrigues Botton, Erica L. Woodahl, Stuart A. Scott, Teri E. Klein, Victoria M. Pratt, Ann K. Daly, Andrea Gaedigk

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.

Original language	English
Pages (from-to)	662-676
Number of pages	15
Journal	Clinical Pharmacology and Therapeutics
Volume	110
Issue number	3
DOIs	https://doi.org/10.1002/cpt.2333
State	Published - Sep 2021

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10.1002/cpt.2333

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Sangkuhl, K., Claudio-Campos, K., Cavallari, L. H., Agundez, J. A. G., Whirl-Carrillo, M., Duconge, J., Del Tredici, A. L., Wadelius, M., Rodrigues Botton, M., Woodahl, E. L., Scott, S. A., Klein, T. E., Pratt, V. M., Daly, A. K., & Gaedigk, A. (2021). PharmVar GeneFocus: CYP2C9. Clinical Pharmacology and Therapeutics, 110(3), 662-676. https://doi.org/10.1002/cpt.2333

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title = "PharmVar GeneFocus: CYP2C9",

abstract = "The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.",

author = "Katrin Sangkuhl and Karla Claudio-Campos and Cavallari, {Larisa H.} and Agundez, {Jose A.G.} and Michelle Whirl-Carrillo and Jorge Duconge and {Del Tredici}, {Andria L.} and Mia Wadelius and {Rodrigues Botton}, Mariana and Woodahl, {Erica L.} and Scott, {Stuart A.} and Klein, {Teri E.} and Pratt, {Victoria M.} and Daly, {Ann K.} and Andrea Gaedigk",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Clinical Pharmacology & Therapeutics {\textcopyright} 2021 American Society for Clinical Pharmacology and Therapeutics",

year = "2021",

month = sep,

doi = "10.1002/cpt.2333",

language = "English",

volume = "110",

pages = "662--676",

journal = "Clinical Pharmacology and Therapeutics",

issn = "0009-9236",

publisher = "Wiley-Blackwell",

number = "3",

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TY - JOUR

T1 - PharmVar GeneFocus

T2 - CYP2C9

AU - Sangkuhl, Katrin

AU - Claudio-Campos, Karla

AU - Cavallari, Larisa H.

AU - Agundez, Jose A.G.

AU - Whirl-Carrillo, Michelle

AU - Duconge, Jorge

AU - Del Tredici, Andria L.

AU - Wadelius, Mia

AU - Rodrigues Botton, Mariana

AU - Woodahl, Erica L.

AU - Scott, Stuart A.

AU - Klein, Teri E.

AU - Pratt, Victoria M.

AU - Daly, Ann K.

AU - Gaedigk, Andrea

PY - 2021/9

Y1 - 2021/9

N2 - The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.

AB - The Pharmacogene Variation Consortium (PharmVar) catalogues star (*) allele nomenclature for the polymorphic human CYP2C9 gene. Genetic variation within the CYP2C9 gene locus impacts the metabolism or bioactivation of many clinically important drugs, including nonsteroidal anti-inflammatory drugs, phenytoin, antidiabetic agents, and angiotensin receptor blockers. Variable CYP2C9 activity is of particular importance regarding efficacy and safety of warfarin and siponimod as indicated in their package inserts. This GeneFocus provides a comprehensive overview and summary of CYP2C9 and describes how haplotype information catalogued by PharmVar is utilized by the Pharmacogenomics Knowledgebase and the Clinical Pharmacogenetics Implementation Consortium.

UR - http://www.scopus.com/inward/record.url?scp=85109677369&partnerID=8YFLogxK

U2 - 10.1002/cpt.2333

DO - 10.1002/cpt.2333

M3 - Review article

C2 - 34109627

AN - SCOPUS:85109677369

SN - 0009-9236

VL - 110

SP - 662

EP - 676

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 3

ER -

PharmVar GeneFocus: CYP2C9

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