Phomopsolides and related compounds from the alga-associated fungus, Penicillium clavigerum

Andrea A. Stierle, Donald B. Stierle, Grant G. Mitman, Shea Snyder, Christophe Antczak, Hakim Djaballah

Research output: Contribution to journalArticlepeer-review


For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3 ) and (4 ), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9 ), and phompyrone (10) and the new compound berkbenzofuran thioester (11 ). Compounds 5 and 6 were potent inhibitors (IC50 < 10 μM) of specific and established human cancer cell lines.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNatural Product Communications
Issue number1
StatePublished - Jan 2014


  • Extremophiles
  • Matrix metalloproteinase-3 inhibitors
  • Phomopsolides
  • Secondary metabolites
  • Thioesters


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