Phomopsolides and related compounds from the alga-associated fungus, Penicillium clavigerum

Andrea A. Stierle, Donald B. Stierle, Grant G. Mitman, Shea Snyder, Christophe Antczak, Hakim Djaballah

Research output: Contribution to journalArticlepeer-review

Abstract

For the past fifteen years we have studied the secondary metabolites of extremophilic fungi from the Berkeley Pit, an abandoned acid mine waste lake. Fungi associated with an acid-tolerant alga have also been harvested from the Pit. Penicillium clavigerum Demelius was isolated from the green alga Chlorella vulgaris Beyerinck [Beijerinck]. In culture it produced the known compounds phomfuranone (1), patulin (2), dimethylphthalides (3 ) and (4 ), phomopsolide A (5), phomopsolide C (6), phomopsolide B (7), phomopsolide E (8), phomopsolide F (9 ), and phompyrone (10) and the new compound berkbenzofuran thioester (11 ). Compounds 5 and 6 were potent inhibitors (IC50 < 10 μM) of specific and established human cancer cell lines.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNatural Product Communications
Volume9
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • Extremophiles
  • Matrix metalloproteinase-3 inhibitors
  • Phomopsolides
  • Secondary metabolites
  • Thioesters

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