Plasma-binding globulins and acute stress response

C. W. Breuner, S. E. Lynn, G. E. Julian, J. M. Cornelius, B. J. Heidinger, O. P. Love, R. S. Sprague, H. Wada, B. A. Whitman

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Within studies of acute stress physiology an increase in glucocorticoid secretion is thought to be the primary mediator of tissue response to stress. Corticosteroid-binding globulin may regulate tissue availability of steroids, but has not been considered a dynamic component of the acute stress response. Here, we examined CBG level over the common 60-minute time frame in an acute capture and handling protocol to investigate whether CBG capacity is dynamic or static over short stressors. Using a comparative approach, we measured CBG response to capture and handling stress in nine species of birds, representing five orders and nine families. CBG capacity significantly declined within 30-60 minutes of capture in five of the nine species examined. This decline may serve to significantly increase the level of corticosterone reaching tissues during acute stress.

Original languageEnglish
Pages (from-to)260-268
Number of pages9
JournalHormone and Metabolic Research
Issue number4
StatePublished - Apr 2006


  • Birds
  • Corticosterone
  • Free CORT


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