Pneumocystic carinii pneumonia in a term newborn infant with a transiently depressed T lymphocyte count, primarily of cells carrying the CD4 antigen

Robert W. Hostoffer, Amy Litman, Paul G. Smith, Howard S. Jacobs, Michael F. Tosi

Research output: Contribution to journalArticlepeer-review

Abstract

A term infant without infection by human immunodeficlency virus had pneumocystis pneumonia at 17 days of life. Initial counts of T lymphocytes carrying the CD4 antigen were ≈50% of the lower limits of normal; later the counts of T lymphocytes carrying the CD3 and CD8 antigens decreased as well. By 7 weeks after resolution of the pneumonia, CD3+, CD4+ and CD8+ cell counts had returned to normal. These observations suggest that a primary transient deficiency of T cell production or maturation, especially involving CD4+ cells, may occur in otherwise normal newborn infants.

Original languageEnglish
Pages (from-to)792-794
Number of pages3
JournalJournal of Pediatrics
Volume122
Issue number5
DOIs
StatePublished - May 1993

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