Pnictogen-directed synthesis of discrete disulfide macrocycles

Mary S. Collins, Matthew E. Carnes, Aaron C. Sather, Orion B. Berryman, Lev N. Zakharov, Simon J. Teat, Darren W. Johnson

Research output: Contribution to journalArticlepeer-review


Cyclic disulfide macrocycles were rapidly synthesized cleanly and selectively from rigid dithiols via oxidation with iodine when activated by pnictogen additives (As and Sb). Macrocycles were confirmed by 1H-NMR spectroscopy and X-ray crystallography. A p-xylyl-based disulfide trimer and tetramer crystallized in hollow, stacked columns stabilized by intermolecular, sulfur⋯sulfur close contacts.

Original languageEnglish
Pages (from-to)6599-6601
Number of pages3
JournalChemical Communications
Issue number59
StatePublished - Jun 27 2013


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