Proteins binding to the promoter region of the operon encoding the major outer surface proteins OspA and OspB of Borrelia burgdorferi

Neil Margolis, D. Scott Samuels

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of the major outer surface proteins OspA and OspB in Borrelia burgdorferi varies among strains and during in vitro cultivation. We examined B. burgdorferi CA-11.2A for the presence of proteins that bind to the ospAB operon promoter region. Three major DNA-protein complexes were detected using a mobility shift assay; one of these complexes was due to sequence-specific binding. These proteins may be involved in the regulation of ospAB transcription and the pathogenesis of Lyme disease.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalMolecular Biology Reports
Volume21
Issue number3
DOIs
StatePublished - Oct 1995

Keywords

  • Borrelia burgdorferi
  • DNA-binding protein
  • Lyme disease
  • outer membrane protein
  • transcriptional regulation

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