TY - JOUR
T1 - Proteins of bartonella bacilliformis
T2 - Candidates for vaccine development
AU - Henriquez-Camacho, Cesar
AU - Ventosilla, Palmira
AU - Minnick, Michael F.
AU - Ruiz, Joaquim
AU - Maguiña, Ciro
N1 - Publisher Copyright:
© 2015 Cesar Henriquez-Camacho et al.
PY - 2015
Y1 - 2015
N2 - Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
AB - Bartonella bacilliformis is the etiologic agent of Carrión's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrión's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
UR - http://www.scopus.com/inward/record.url?scp=84941702927&partnerID=8YFLogxK
U2 - 10.1155/2015/702784
DO - 10.1155/2015/702784
M3 - Review article
AN - SCOPUS:84941702927
SN - 1687-9767
VL - 2015
JO - International Journal of Peptides
JF - International Journal of Peptides
M1 - 702784
ER -
