Proteomic biomarkers for bisphenol A-early exposure and women's thyroid cancer

Ho Sun Lee, Yunkyeong Kang, Kyung Tae, Gyu Un Bae, Jong Y. Park, Yoon Hee Cho, Mihi Yang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Purpose For the target treatment and prevention of women's increased thyroid cancer, we focused on risks of environmental exposure to endocrine disrupting chemicals, particularly bisphenol A (BPA), and its high susceptible exposure-timing, particularly early exposure in lives. Materials and Methods Female ICR mice were exposed to BPA in utero and in early life (15, 75, and 300 mg/L of drinking water via pregnant mice and lactation). We identified BPA-responsive proteins in mice thyroid by two-dimensional gel electrophoresis, image analyses, and electrospray ionization quadrupole time-of-flight mass spectrometry. We further analyzed expression of the BPA-responsive proteins in women thyroid cancer patients (n = 28). Results We found the altered 17 proteins in BPA dose-dependent manner among the thyroid tissues of offspring mice and identified nine proteins of them, including Anxa6, Atp5b, Hspa5, and Vcp, etc. In addition, we observed the positive association between blood BPA levels and mRNA expression of the ANXA6 and VCP not in normal but thyroid cancer tissues. Conclusion Our study provides ANXA6 and VCP as proteomic biomarkers for BPA-early life exposure and their potential for women's thyroid cancer.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalCancer Research and Treatment
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2018

Keywords

  • Annexin A6
  • Bisphenol A
  • Endocrine disruptors
  • Maternal exposure
  • Proteomics
  • Thyroid neoplasms
  • Valosin-containing protein
  • Women

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